Opportunity Information: Apply for RFA ES 25 002
The Environmental Health Sciences Core Centers Program (P30 Clinical Trials Optional), announced by the National Institutes of Health (NIH) under Funding Opportunity Number RFA-ES-25-002 (CFDA 93.113), supports the creation or continued operation of Environmental Health Sciences Core Centers (EHSCCs). These centers are meant to function as major intellectual hubs for environmental health science research, bringing together groups of investigators and giving them shared infrastructure that makes their individually funded and collaborative work stronger, faster, and more cost-effective. The program positions EHSCCs as field-leading entities expected to help drive progress aligned with the NIEHS 2025-2029 Strategic Plan, with an emphasis on staying ahead of emerging environmental health issues and shaping the direction of the broader research community.
At its core, the program is about building and sustaining high-value, shared research capacity rather than funding a single standalone research project. EHSCCs provide critical shared facilities, services, and resources (often referred to as "cores") that investigators can access to support environmental health sciences research. The overall scientific goal is to improve understanding of how environmental exposures interact with human biology to influence disease and health outcomes. A key expectation is that centers will be able to identify and capitalize on new or rapidly developing issues in the field, helping research teams pivot toward important questions as evidence and public health needs evolve.
Community engagement and translation to public health impact are highlighted as central approaches within this program. In practical terms, that means EHSCCs are expected not only to support rigorous environmental health research, but also to strengthen the pathways that connect science to real-world outcomes, including communication with communities affected by environmental exposures and efforts that move findings toward prevention, interventions, or policy-relevant knowledge. The "clinical trials optional" designation indicates that clinical trials may be included when appropriate, but they are not required for an application to be responsive.
Eligibility for this discretionary grant program is broad and includes many types of U.S.-based organizations and government entities. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofit organizations (with or without 501(c)(3) status, as long as they are not institutions of higher education in those categories); for-profit organizations other than small businesses; and small businesses. The announcement also explicitly notes other eligible applicant types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
Foreign eligibility is restricted in a way that is typical for NIH center programs. Non-domestic (non-U.S.) entities are not eligible to apply as applicant organizations, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components as defined by the NIH Grants Policy Statement are allowed, meaning a U.S.-based applicant may include certain well-justified foreign collaborations or activities within the project structure when they meet NIH policy requirements.
Key administrative details included in the notice are that the opportunity was created on November 14, 2024, the original closing date is January 29, 2027, and the funding instrument is a grant using the P30 center mechanism. The award ceiling and expected number of awards were not specified in the provided source data. Overall, the opportunity is best understood as a way for NIEHS to invest in durable, shared research ecosystems that elevate environmental health science, expand capacity for cutting-edge exposure-biology-disease research, and strengthen community-engaged and translational pathways that can ultimately improve public health.Apply for RFA ES 25 002
- The National Institutes of Health in the environment, health sector is offering a public funding opportunity titled "Environmental Health Sciences Core Centers Program (P30 Clinical Trials Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113.
- This funding opportunity was created on 2024-11-14.
- Applicants must submit their applications by 2027-01-29.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the Environmental Health Sciences Core Centers Program (P30 Clinical Trials Optional)?
The Environmental Health Sciences Core Centers Program supports the creation or continued operation of Environmental Health Sciences Core Centers (EHSCCs). These centers are designed to serve as major intellectual hubs for environmental health sciences research by bringing together groups of investigators and providing shared infrastructure ("cores") that strengthens and accelerates both individually funded and collaborative research.
Who is offering this funding opportunity?
This opportunity is offered by the National Institutes of Health (NIH), and it is associated with the National Institute of Environmental Health Sciences (NIEHS) based on the program description and expectations tied to the NIEHS 2025-2029 Strategic Plan.
What is the Funding Opportunity Number (FOA) for this program?
The Funding Opportunity Number is RFA-ES-25-002.
What is the CFDA number listed for this opportunity?
The CFDA number provided is 93.113.
What mechanism or type of award is used for this program?
The funding instrument is a grant using the P30 center mechanism, which is intended to support shared resources and facilities that serve a community of investigators.
What is the main purpose of an Environmental Health Sciences Core Center (EHSCC)?
The main purpose is to build and sustain high-value, shared research capacity. EHSCCs provide shared facilities, services, and resources ("cores") that investigators can access to make environmental health sciences research stronger, faster, and more cost-effective.
Is this program intended to fund a single research project?
No. The program is described as being about building and sustaining shared research capacity rather than funding a single standalone research project. The center structure is meant to support multiple investigators and multiple research efforts through shared infrastructure.
What kinds of resources do EHSCCs provide?
EHSCCs provide shared facilities, services, and resources, often referred to as "cores," that investigators can use to support their environmental health sciences research.
What scientific focus does this program emphasize?
The overall scientific goal is to improve understanding of how environmental exposures interact with human biology to influence disease and health outcomes.
How are centers expected to contribute to the broader field of environmental health sciences?
Centers are positioned as field-leading entities expected to drive progress aligned with the NIEHS 2025-2029 Strategic Plan. They are expected to stay ahead of emerging environmental health issues and help shape the direction of the broader research community.
Does the program emphasize emerging or rapidly developing environmental health issues?
Yes. A key expectation is that centers will be able to identify and capitalize on new or rapidly developing issues, enabling research teams to pivot toward important questions as evidence and public health needs evolve.
How important are community engagement and translation to public health impact in this program?
They are highlighted as central approaches. Centers are expected to strengthen pathways that connect science to real-world outcomes, including communication with communities affected by environmental exposures and efforts that move findings toward prevention, interventions, or policy-relevant knowledge.
What does "Clinical Trials Optional" mean for this opportunity?
"Clinical trials optional" means clinical trials may be included when appropriate, but they are not required for an application to be considered responsive.
Which organizations are eligible to apply?
Eligibility is broad and includes many U.S.-based organizations and government entities, including state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofit organizations (with or without 501(c)(3) status, as long as they are not institutions of higher education in those categories); for-profit organizations other than small businesses; and small businesses.
Are minority-serving institutions and community-based organizations included in the eligible applicant types?
Yes. The announcement explicitly notes eligibility for applicant types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also mentions faith-based or community-based organizations and regional organizations.
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are explicitly noted as eligible applicant types.
Are eligible federal agencies allowed to apply?
Yes. Eligible federal agencies are explicitly included among the eligible applicant types.
Can foreign organizations apply as the primary applicant?
No. Non-domestic (non-U.S.) entities are not eligible to apply as applicant organizations.
Can a non-domestic component of a U.S. organization apply?
No. Non-domestic components of U.S. organizations are also not eligible to apply as applicant organizations.
Are foreign components allowed in any form?
Yes. Foreign components (as defined by the NIH Grants Policy Statement) are allowed. This means a U.S.-based applicant may include well-justified foreign collaborations or activities within the project structure when they meet NIH policy requirements.
When was this funding opportunity created?
The opportunity was created on November 14, 2024.
What is the original closing date for this opportunity?
The original closing date is January 29, 2027.
How many awards will be made under this announcement?
The expected number of awards was not specified in the provided information.
Is there an award ceiling (maximum award amount) listed?
The award ceiling was not specified in the provided information.
What is the overall value proposition of this program for environmental health research?
The program is intended as a way for NIEHS to invest in durable, shared research ecosystems that elevate environmental health science, expand capacity for cutting-edge exposure-biology-disease research, and strengthen community-engaged and translational pathways that can ultimately improve public health.
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