Opportunity Information: Apply for RFA CA 17 045
The Immuno-Oncology Translational Network (IOTN): Cancer Immunotherapy Research Projects (U01) funding opportunity (RFA-CA-17-045) is a National Institutes of Health (NIH) cooperative agreement program created under the Beau Biden Cancer Moonshot initiative. Its central purpose is to speed up progress in cancer immunotherapy by building a focused translational science network that works specifically on immunotherapy approaches for adult cancers. This aligns with the Cancer Moonshot Blue Ribbon Panel (BRP) scientific priority Recommendation B, which called for a dedicated, collaborative network to move promising immune-based discoveries more quickly toward practical, patient-relevant outcomes.
The program emphasizes team science and coordinated collaboration as the core operating model. Rather than supporting isolated projects that work independently, the IOTN concept is designed to connect investigators and institutions so they can jointly accelerate the discovery of new immune targets and rapidly evaluate novel immune-based therapies. A major thrust is testing and refining combination strategies, reflecting the reality that many cancers evade immune attack through multiple mechanisms and may require multi-pronged immune approaches to achieve durable responses. The FOA also explicitly includes prevention as a goal, meaning projects can focus not only on eliminating established adult cancers, but also on immune-based strategies that could stop cancers before they develop.
Mechanistically, this is a U01 cooperative agreement, which typically means NIH expects to have substantial scientific and programmatic involvement during the life of the award. In practice, this often translates into more structured milestones, cross-project coordination, and active engagement with NIH staff compared with a standard investigator-initiated grant. The activity category is listed under health and the broader environment/health domain, and the relevant CFDA program numbers include 93.113, 93.121, 93.273, 93.353, and 93.853.
In terms of who can apply, eligibility is broad across U.S.-based organizations and includes many government, academic, nonprofit, and commercial entities. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (as long as they are not institutions of higher education in those categories); for-profit organizations other than small businesses; small businesses; and other organizations that meet NIH requirements. The FOA also highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.
At the same time, there are clear limits on foreign involvement. Non-domestic (non-U.S.) entities and non-domestic (non-U.S.) components of U.S. organizations are not eligible to apply as applicants. However, foreign components are allowed when they meet the NIH definition in the NIH Grants Policy Statement, meaning U.S. applicants may include certain foreign elements in the project when well-justified and compliant with NIH policy.
Key administrative details from the source listing include an original closing date of January 16, 2018, and an award ceiling of $500,000. The listing shows the expected number of awards as unspecified in the provided fields. The opportunity was created on October 10, 2017. Overall, the program is best understood as a Moonshot-driven, network-oriented translational immuno-oncology funding mechanism intended to push immune target discovery and therapy development forward faster by using coordinated, collaborative research projects aimed at treating and preventing adult cancers.Apply for RFA CA 17 045
- The National Institutes of Health in the environment, health sector is offering a public funding opportunity titled "Immuno-Oncology Translational Network (IOTN): Cancer Immunotherapy Research Projects (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.273, 93.353, 93.853.
- This funding opportunity was created on 2017-10-10.
- Applicants must submit their applications by 2018-01-16. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Transition to Independent Environmental Health Research (TIEHR) Career Transition Award (K01 Clinical Trial Required) Apply for PAR 18 261 Funding Number: PAR 18 261 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Transition to Independent Environmental Health Research (TIEHR) Career Transition Award (K01 Clinical Trial Not Allowed) Apply for PAR 18 291 Funding Number: PAR 18 291 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| The Role of the Microbiome in the Developmental Origins of Health and Disease (DOHaD) (R01 Clinical Trial Not Allowed) Apply for RFA ES 18 005 Funding Number: RFA ES 18 005 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
| Revolutionizing Innovative, Visionary Environmental health Research (RIVER) (R35 Clinical Trial Not Allowed) Apply for RFA ES 18 004 Funding Number: RFA ES 18 004 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $600,000 |
| SBIR E-learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 18 006 Funding Number: RFA ES 18 006 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $100,000 |
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| Chronic, Non-Communicable Diseases and Disorders Across the Lifespan: Fogarty International Research Training Award (NCD-LIFESPAN) (D43)(Clinical Trial Optional) Apply for PAR 18 901 Funding Number: PAR 18 901 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Telomeres as Sentinels of Environmental Exposures, Psychosocial Stress, and Disease Susceptibility: A Methods Comparison Study (U01 Clinical Trial Optional) Apply for RFA AG 19 023 Funding Number: RFA AG 19 023 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $200,000 |
| Research Network on Telomeres as Sentinels of Environmental Exposures, Psychosocial Stress, and Disease Susceptibility (U24 Clinical Trial Not Allowed) Apply for RFA AG 19 022 Funding Number: RFA AG 19 022 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $345,000 |
| Human Health Exposure Analysis Resource: Data Repository, Analysis and Science Center (U2C Clinical Trial Not Allowed) Apply for RFA ES 18 014 Funding Number: RFA ES 18 014 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $1,700,000 |
| Human Health Exposure Analysis Resource: Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA ES 18 010 Funding Number: RFA ES 18 010 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $700,000 |
| Human Health Exposure Analysis Resource: UnTargeted Exposure Analysis Laboratories (U2C Clinical Trial Not Allowed) Apply for RFA ES 18 012 Funding Number: RFA ES 18 012 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $1,500,000 |
| Human Health Exposure Analysis Resource: Targeted Exposure Analysis Laboratories (U2C Clinical Trial Not Allowed) Apply for RFA ES 18 011 Funding Number: RFA ES 18 011 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $1,500,000 |
| Human Health Exposure Analysis Resource: Environmental Exposure Analysis Laboratories (U2C Clinical Trial Not Allowed) Apply for RFA ES 18 013 Funding Number: RFA ES 18 013 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $700,000 |
| Maintain and Enrich Resource Infrastructure for Existing Environmental Epidemiology Cohorts (R24 Clinical Trial Not Allowed) Apply for RFA ES 18 009 Funding Number: RFA ES 18 009 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $250,000 |
| Virtual Consortium for Translational/Transdisciplinary Environmental Research (ViCTER) (R01 Clinical Trial Optional) Apply for RFA ES 18 007 Funding Number: RFA ES 18 007 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
| Enhancing Data Management and Sharing in NIEHS-Funded Research Grants (Admin Supp Clinical Trial Not Allowed) Apply for PA 19 025 Funding Number: PA 19 025 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $75,000 |
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