Opportunity Information: Apply for RFA OD 22 019
This NIH funding opportunity (RFA-OD-22-019) is a limited-competition cooperative agreement (UG3/UH3) aimed at renewing and extending the work of existing Environmental influences on Child Health Outcomes (ECHO) Cohort Study Sites specifically for pediatric follow-up. The central purpose is to strengthen the ECHO Cohort's ability to study how a wide spectrum of early-life exposures, ranging from social and environmental conditions to biological factors, shape child health and development across diverse populations. The work is organized around ECHO's five priority pediatric outcome areas: pre-, peri-, and postnatal health; upper and lower airway health; obesity; neurodevelopment; and positive health.
The FOA is designed around three main expectations for funded sites. First, awardees are expected to actively lead and participate in collaborative ECHO Cohort science, meaning the research agenda and deliverables are driven at the consortium level rather than by individual sites pursuing independent questions. Second, sites must continue following up participants who are already enrolled in the ECHO Cohort, emphasizing continuity of longitudinal data and sustained engagement with families over time. Third, sites must implement the standardized ECHO Cohort Data and Biospecimen Collection Protocol, including using the consortium's centralized data capture infrastructure (for example, REDCap Central). In practical terms, the funding is meant to support harmonized data and specimen collection so the cohort can be analyzed as a unified national resource rather than a set of separate local studies.
A key limitation is that this FOA does not support site-specific analyses or site-specific science. In other words, the goal is not to fund individual cohorts to run their own standalone analytic projects, but to fund coordinated operations and standardized follow-up that feed into ECHO-wide research. Consistent with the title, clinical trials are not allowed under this announcement.
Eligibility is restricted in an important way: only current ECHO Cohort awardees can apply, reflecting its "renewal" and limited-competition nature. While the general NIH eligibility list includes many types of entities (such as state, county, and local governments; public and private institutions of higher education; nonprofit and for-profit organizations; small businesses; and tribal entities including federally recognized tribal governments and other tribal organizations), the practical gatekeeping requirement is prior/current ECHO Cohort award status. The announcement also highlights categories of institutions and organizations that may be eligible within NIH rules, including Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.
The award mechanism is a cooperative agreement, which typically means NIH will have substantial programmatic involvement compared with a standard research project grant. The project structure uses a two-phase UG3/UH3 model over a potential total of seven years, with transition from the UG3 phase to the UH3 phase dependent on meeting milestones and demonstrating successful performance. This staged design is meant to ensure sites can demonstrate readiness and capability early, then scale into the full implementation period.
This FOA is part of a broader set of parallel, companion ECHO funding announcements that together cover other pieces of the consortium. Those companion FOAs include opportunities for cohort sites that both follow existing participants and recruit new pregnant participants (and the resulting offspring, and when available the conceiving partner), an open competition focused on recruiting new pregnant participants, and separate FOAs for major infrastructure components such as an ECHO Coordinating Center, Data Analysis Center, Measurement Core, and Laboratory Core. In other words, this particular FOA focuses narrowly on renewing current cohort sites for pediatric follow-up and standardized protocol implementation, while other announcements address recruitment expansion and central consortium operations.
Administrative details from the posted record include the sponsoring agency (National Institutes of Health), the opportunity category (discretionary), and the activity categories spanning education, environment, food and nutrition, health, and related human services fields. The original closing date listed is November 21, 2022. The record also notes restrictions on non-U.S. applicants and components: non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are not eligible to apply, though foreign components are permitted when they meet the NIH Grants Policy Statement definition and requirements.Apply for RFA OD 22 019
- The National Institutes of Health in the education, environment, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "Limited Competition: Environmental influences on Child Health Outcomes (ECHO) Cohort Study Sites for Pediatric Follow Up. Clinical Trial Not Allowed (UG3/UH3)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.213, 93.233, 93.242, 93.273, 93.279, 93.307, 93.310, 93.313, 93.350, 93.361, 93.399, 93.837, 93.838, 93.839, 93.840, 93.847, 93.853, 93.855, 93.865, 93.866, 93.879.
- This funding opportunity was created on 2022-08-30.
- Applicants must submit their applications by 2022-11-21. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Funding Opportunity |
|---|
| Environmental influences on Child Health Outcomes (ECHO) Data Analysis Center (U24) Clinical Trial Not Allowed Apply for RFA OD 22 022 Funding Number: RFA OD 22 022 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Environmental influences on Child Health Outcomes (ECHO) Pregnancy and Pediatric Cohort Study Sites. Clinical Trial Not Allowed (UG3/UH3) Apply for RFA OD 22 018 Funding Number: RFA OD 22 018 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Environmental influences on Child Health Outcomes (ECHO) Measurement Core (U24) Clinical Trial Not Allowed Apply for RFA OD 22 020 Funding Number: RFA OD 22 020 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32) Apply for PA 23 048 Funding Number: PA 23 048 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Addressing the Impact of Structural Racism and Discrimination on Minority Health and Health Disparities (R01 - Clinical Trial Optional) Apply for PAR 23 112 Funding Number: PAR 23 112 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $500,000 |
| Emergency Award: Novel Insights through Cross-Site Analyses of Existing RADx-UP Data (R21 Clinical Trial Not Allowed) Apply for RFA OD 23 050 Funding Number: RFA OD 23 050 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $275,000 |
| Native American Research Centers for Health (NARCH) (S06 Clinical Trial Optional) Apply for PAR 23 166 Funding Number: PAR 23 166 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Collaborative Partnership to Advance Global Health Research (U01 Clinical Trial Not Allowed) Apply for PAR 23 203 Funding Number: PAR 23 203 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $2,360,000 |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions with NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) Apply for PA 23 260 Funding Number: PA 23 260 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) Apply for PA 23 272 Funding Number: PA 23 272 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) Apply for PA 23 262 Funding Number: PA 23 262 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) Apply for PA 23 261 Funding Number: PA 23 261 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (Parent F31-Diversity) Apply for PA 23 271 Funding Number: PA 23 271 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed) Apply for PA 24 141 Funding Number: PA 24 141 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed) Apply for PA 24 185 Funding Number: PA 24 185 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required) Apply for PA 24 184 Funding Number: PA 24 184 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Required) Apply for PA 24 190 Funding Number: PA 24 190 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Not Allowed) Apply for PA 24 191 Funding Number: PA 24 191 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required) Apply for PA 24 175 Funding Number: PA 24 175 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed) Apply for PA 24 176 Funding Number: PA 24 176 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
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