Opportunity Information: Apply for PAR 24 212
The NINDS Alzheimers Disease and Alzheimers Disease-Related Dementias (AD/ADRD) Advanced Postdoctoral Career Transition Award to Promote Diversity is an NIH career development funding opportunity that uses the K99/R00 mechanism to help advanced postdoctoral researchers move from mentored training into independent faculty positions. It is specifically aimed at building and sustaining a strong pipeline of independent investigators from diverse backgrounds who are committed to research on Alzheimers disease and Alzheimers disease-related dementias. In practical terms, the program is meant to reduce the gap between being a postdoc with a mentor and becoming an independent, tenure-track (or equivalent) researcher with the resources and credibility needed to launch a long-term research program in the AD/ADRD space.
The structure of the award is a two-phase transition model. The K99 phase supports the applicant while they are still in a mentored postdoctoral position, focusing on completing key research and career development activities that position them for independence. The R00 phase then provides support after the awardee secures an independent, tenure-track or equivalent faculty appointment, helping them establish their own lab or research program. The overall idea is that recipients are not only doing impactful AD/ADRD research during the mentored period, but also leaving that period with a clear trajectory, preliminary results, and a credible plan for independent funding and publication as they enter a faculty role.
A central feature of this particular announcement is its clinical trial limitation. This FOA is designated "Independent Clinical Trial Not Allowed," meaning applicants cannot propose to lead an independent clinical trial, a clinical trial feasibility study, or an ancillary study to a clinical trial as the main project. However, the announcement does allow applicants to gain experience in clinical trials as part of their training as long as the trial is led by a mentor or co-mentor. This makes the opportunity suitable for candidates whose work may touch human subjects research or clinical trial environments, but whose proposed K99/R00 research plan is not centered on serving as the responsible trial leader.
Eligibility and institutional participation are broad, reflecting NIH norms for grant programs, and include many types of organizations that may host awardees. Eligible applicant organizations listed include public and private institutions of higher education, state and local governments, Native American tribal governments and organizations, independent school districts, special district governments, public housing authorities/Indian housing authorities, nonprofits (both 501(c)(3) and non-501(c)(3)), for-profit entities other than small businesses, and small businesses, among others. The FOA also highlights additional eligible organizational categories often associated with workforce diversity and capacity building, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and eligible federal agencies.
There are also important geographic and foreign involvement rules. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply. At the same time, foreign components, as NIH defines them in the NIH Grants Policy Statement, are allowed, meaning certain collaborations or project elements abroad may be permissible if they meet NIH policy requirements and are appropriately justified, even though the applicant organization itself must be domestic.
From an administrative standpoint, this opportunity is issued by the National Institutes of Health, specifically through NINDS, and is categorized as a discretionary grant opportunity in the health area. The funding opportunity number is PAR-24-212, and the associated CFDA numbers are 93.853 and 93.866. The opportunity record notes an original closing date of 2027-07-12, indicating a multi-year window during which applications may be accepted according to the FOA schedule. The listing does not specify an award ceiling or expected number of awards in the provided source text, so applicants typically need to consult the full FOA for budget details, allowable costs, duration of each phase, and the receipt dates and review cycles.
Overall, this K99/R00 program is best understood as a targeted career transition award designed to promote diversity in the AD/ADRD research workforce by providing structured support across the critical shift from postdoctoral training to an independent faculty role, while keeping the proposed research outside the scope of applicant-led independent clinical trials.Apply for PAR 24 212
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NINDS Alzheimers Disease-Related Dementias (ADRD) Advanced Postdoctoral Career Transition Award to Promote Diversity (K99/R00 Independent Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853, 93.866.
- This funding opportunity was created on 2024-06-24.
- Applicants must submit their applications by 2027-07-12.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NINDS AD/ADRD Advanced Postdoctoral Career Transition Award to Promote Diversity (K99/R00) - PAR-24-212
What is this funding opportunity?
This is an NIH career development grant from the National Institute of Neurological Disorders and Stroke (NINDS) that uses the K99/R00 mechanism to help advanced postdoctoral researchers transition from mentored postdoctoral training into independent faculty positions focused on Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD).
What is the main purpose of the award?
The award is designed to reduce the gap between being a mentored postdoc and becoming an independent, tenure-track (or equivalent) investigator. It supports both advanced training and the launch of an independent AD/ADRD research program, with a specific emphasis on promoting diversity and strengthening the pipeline of independent investigators from diverse backgrounds in AD/ADRD research.
What career stage is this program intended for?
It is intended for advanced postdoctoral researchers who are still in a mentored postdoctoral position and are preparing to move into an independent faculty appointment.
How does the K99/R00 structure work?
The award has two phases:
- K99 phase (mentored phase): Supports the applicant while they remain in a mentored postdoctoral role, focusing on completing key research and career development activities that position them for independence.
- R00 phase (independent phase): Provides support after the awardee secures an independent, tenure-track or equivalent faculty appointment, helping them establish their own lab or independent research program.
What kinds of outcomes is the program trying to support?
Based on the description provided, the program aims to help awardees leave the mentored period with a strong trajectory toward independence, including preliminary results, a credible research plan, and a path toward independent funding and publication in the AD/ADRD field.
Is this opportunity focused specifically on Alzheimer's disease and related dementias?
Yes. The stated focus is research on Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD).
Are independent clinical trials allowed under this FOA?
No. This funding opportunity is designated as "Independent Clinical Trial Not Allowed." Applicants may not propose to lead an independent clinical trial, a clinical trial feasibility study, or an ancillary study to a clinical trial as the main project.
Can applicants get clinical trial experience at all?
Yes. Clinical trial experience is allowed as part of training, as long as the clinical trial is led by a mentor or co-mentor rather than the applicant as the responsible leader.
If my research involves human subjects, does that automatically make it ineligible?
Not necessarily. The limitation described is specifically about the applicant leading an independent clinical trial (including feasibility or ancillary studies) as the main project. The provided text indicates that work that "may touch human subjects research or clinical trial environments" can still be appropriate, as long as the application is not centered on the applicant serving as the clinical trial leader.
Who is the sponsoring agency and institute?
The sponsoring agency is the National Institutes of Health (NIH), and the opportunity is issued through the National Institute of Neurological Disorders and Stroke (NINDS).
What is the funding opportunity number?
The funding opportunity number is PAR-24-212.
What CFDA numbers are associated with this opportunity?
The associated CFDA numbers listed are 93.853 and 93.866.
What type of grant is this categorized as?
It is described as a discretionary grant opportunity in the health area and is a career development funding opportunity using the NIH K99/R00 mechanism.
What types of applicant organizations are eligible?
The eligible applicant organizations listed are broad and include many categories typically recognized under NIH policies, including:
- Public and private institutions of higher education
- State and local governments
- Native American tribal governments and organizations
- Independent school districts
- Special district governments
- Public housing authorities/Indian housing authorities
- Nonprofits (501(c)(3) and non-501(c)(3))
- For-profit entities other than small businesses
- Small businesses
- Faith-based or community-based organizations
- Eligible federal agencies
Are certain institution types specifically highlighted in the eligibility description?
Yes. The description highlights organizational categories often associated with workforce diversity and capacity building, including:
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving Institutions
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
Are foreign (non-U.S.) organizations eligible to apply?
No. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply.
Can a U.S. organization apply if part of the project is based outside the United States?
The provided information states that non-domestic components of U.S. organizations are not eligible to apply. However, it also states that foreign components (as defined by NIH in the NIH Grants Policy Statement) are allowed, meaning certain collaborations or elements abroad may be permissible if they meet NIH policy requirements and are appropriately justified, while the applicant organization itself must be domestic.
Does the listing provide the award ceiling or the expected number of awards?
No. The provided source text notes that an award ceiling and the expected number of awards are not specified in the listing information provided.
Where would applicants typically find budget details, durations, and receipt dates?
The description indicates that applicants would typically need to consult the full funding opportunity announcement (FOA) for budget details, allowable costs, the duration of each phase, and the receipt dates and review cycles.
What is the application window or close date mentioned in the opportunity record?
The opportunity record notes an original closing date of 2027-07-12, suggesting a multi-year window during which applications may be accepted according to the FOA schedule.
In plain terms, what problem is this award trying to solve?
In practical terms, it aims to help advanced postdocs bridge the difficult transition from mentored postdoctoral work to independent faculty research by providing structured support across that transition, specifically for researchers committed to AD/ADRD and with an emphasis on strengthening diversity in the independent investigator pipeline.
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| NINDS Alzheimers Disease-Related Dementias (ADRD) Advanced Postdoctoral Career Transition Award (K99/R00 Independent Clinical Trial Not Allowed) Apply for PAR 24 213 Funding Number: PAR 24 213 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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