Opportunity Information: Apply for PAR 25 442
This grant opportunity supports early-stage, exploratory research aimed at targeting medical conditions that have been historically difficult to treat due to the lack of effective therapeutic strategies—specifically focusing on "undruggable" biological targets. Applicants are expected to identify a class of such targets relevant to human disease and propose innovative methods or agents that can selectively modulate one or more targets within that class. The aim is to kickstart new approaches beyond traditional drug development to address complex and persistent health challenges. Clinical trials are not allowed under this funding opportunity. Eligibility extends to a wide range of U.S.-based institutions, including minority-serving academic institutions, tribal organizations, faith-based and community groups, but excludes foreign organizations and non-U.S. components.
Apply for PAR 25 442
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.242, 93.350, 93.855, 93.867.
- This funding opportunity was created on 2025-06-17.
- Applicants must submit their applications by 2028-02-17.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Apply for PAR 25 442
Applicants also applied for:
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| Advancing Strategies to Support Older Adults with Behavioral Health Conditions in the Senior Nutrition Program Setting Apply for HHS 2025 ACL AOA INNU 0036 Funding Number: HHS 2025 ACL AOA INNU 0036 Agency: Administration for Community Living Category: Health Funding Amount: $500,000 |
| Tribal Self-Governance Negotiation Cooperative Agreement Program Apply for HHS 2025 IHS TSGN 0002 Funding Number: HHS 2025 IHS TSGN 0002 Agency: Indian Health Service Category: Health Funding Amount: $84,000 |
| Tribal Self-Governance Planning Cooperative Agreement Program Apply for HHS 2025 IHS TSGP 0002 Funding Number: HHS 2025 IHS TSGP 0002 Agency: Indian Health Service Category: Health Funding Amount: $180,000 |
| Reducing reliance on federal funding and enhancing program effectiveness through data analysis and accountability of community implementing partners in Paraguay Apply for OFOP0002136 Funding Number: OFOP0002136 Agency: U.S. Mission to Paraguay Category: Health Funding Amount: $65,000 |
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| Expanding Strategies for Community Evidence-Based Falls Prevention Programming Apply for HHS 2025 ACL AOA FPSG 0037 Funding Number: HHS 2025 ACL AOA FPSG 0037 Agency: Administration for Community Living Category: Health Funding Amount: $1,250,000 |
| Advancing Strategies to Deliver and Sustain Evidence-Based Chronic Disease Self-Management Education Programs to Support Older Adults with Behavioral Health Conditions Apply for HHS 2025 ACL AOA CSSG 0034 Funding Number: HHS 2025 ACL AOA CSSG 0034 Agency: Administration for Community Living Category: Health Funding Amount: $1,250,000 |
| Drug Supply in Biological Specimens from Emergency Departments Apply for EDS EDS 25 001 Funding Number: EDS EDS 25 001 Agency: Office of National Drug Control Policy Category: Health Funding Amount: $400,000 |
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