Opportunity Information: Apply for RFA DK 22 028
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), within the National Institutes of Health (NIH), is offering an R01 grant opportunity (RFA-DK-22-028) to fund pilot and feasibility clinical trials that integrate social care into routine medical care for people living with type 1 diabetes (T1D). The focus is on pragmatic, real-world interventions that can be carried out within healthcare settings and that directly address adverse social determinants of health (SDoH). In practical terms, the program is looking for projects that build screening for social risks into clinical encounters and then connect patients to concrete supports such as transportation assistance, housing resources, food programs, or other social services that may affect diabetes management and health outcomes.
The central purpose of these studies is twofold. First, awardees are expected to test whether it is feasible to systematically identify social needs during healthcare visits and to implement referral pathways or service linkages in a way that actually works in day-to-day clinical operations. This includes questions like whether the workflow is realistic for clinics, whether patients will complete screening, whether staff can make referrals efficiently, and whether partner organizations can receive and act on referrals. Second, these pilot trials are intended to produce early evidence, or preliminary signals, about whether the intervention improves both the targeted social risks and T1D-related outcomes. While these studies are not positioned as definitive large-scale efficacy trials, they should still generate meaningful early outcome data, including diabetes-specific measures such as glycemic control, alongside outcomes tied to the social needs being addressed.
A major theme of the announcement is collaboration. NIDDK is explicitly trying to stimulate partnerships between healthcare systems (such as endocrinology clinics, diabetes centers, hospitals, and primary care settings), community-based organizations, and social service entities. The idea is that reducing disparities in T1D requires coordinated systems that can bridge medical treatment with the social supports people need to follow treatment plans, access supplies, attend visits, maintain stable housing and food access, and manage the daily burden of T1D. Applications that show strong, practical partnerships and clear referral or service linkage mechanisms are well-aligned with the intent of the program.
This is a discretionary grant opportunity with a funding activity category listed under food and nutrition and health (CFDA 93.847). The award ceiling is $350,000. The FOA is structured as an R01 and is labeled "Clinical Trial Required," meaning the proposed work must include a clinical trial component rather than being purely observational or preparatory. The original closing date for applications was February 29, 2024, and the opportunity was created on January 5, 2023.
Eligibility is broad and includes many types of domestic organizations and government entities. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); Native American tribal organizations (other than federally recognized tribal governments); public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses. The FOA also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, tribal governments that are not federally recognized, and U.S. territories or possessions.
Foreign eligibility is limited. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components are allowed as defined in the NIH Grants Policy Statement, which typically means a U.S.-based applicant can include certain foreign activities or collaborations as a component of the overall project if justified and compliant with NIH policy.
Overall, this FOA is aimed at advancing workable models for embedding social risk screening and service connection into T1D care, using pilot clinical trials to demonstrate feasibility and gather early outcome signals. The broader public health goal is to build evidence and infrastructure for integrated social and medical care approaches that can reduce inequities and improve diabetes outcomes for people whose health is shaped by unmet social needs.Apply for RFA DK 22 028
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Pilot and Feasibility Trials on the Integration of Social and Medical Care for Type 1 Diabetes Mellitus (R01 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2023-01-05.
- Applicants must submit their applications by 2024-02-29. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is this funding opportunity?
This opportunity is an NIH/NIDDK R01 funding announcement (RFA-DK-22-028) to support pilot and feasibility clinical trials that integrate social care into routine medical care for people living with type 1 diabetes (T1D). The emphasis is on pragmatic, real-world interventions that can operate in day-to-day healthcare settings.
Which NIH institute is sponsoring this FOA?
The sponsor is the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), within the National Institutes of Health (NIH).
What is the main goal of the program?
The program is designed to test practical ways to embed social risk screening and service linkage into routine clinical care for T1D, and to generate early evidence that these approaches may improve both social needs and diabetes-related outcomes.
What type of research is NIDDK looking for?
NIDDK is looking for pilot and feasibility clinical trials that address adverse social determinants of health (SDoH) by incorporating screening for social risks during clinical encounters and connecting patients to concrete supports (for example, transportation assistance, housing resources, food programs, or other social services that affect diabetes management).
Does the project have to include a clinical trial?
Yes. The FOA is labeled "Clinical Trial Required," meaning the proposed work must include a clinical trial component rather than being purely observational or preparatory.
Is this meant to be a large, definitive efficacy trial?
No. These are described as pilot and feasibility clinical trials. They are not positioned as definitive large-scale efficacy trials, but they are expected to produce meaningful early outcome data and preliminary signals of benefit.
What are the two central expectations for the studies?
The FOA emphasizes two core aims: (1) demonstrate feasibility of systematically identifying social needs in healthcare visits and implementing referral pathways in real clinical operations, and (2) produce early evidence on whether the intervention improves both targeted social risks and T1D-related outcomes.
What kinds of feasibility questions should the pilot address?
Examples of feasibility issues highlighted include whether clinic workflows are realistic, whether patients complete screening, whether staff can make referrals efficiently, and whether partner organizations can receive and act on referrals.
What outcomes are expected to be measured?
Projects should generate early outcome data that includes diabetes-specific measures such as glycemic control, along with outcomes related to the social needs being addressed (for example, improvements in access to food, housing stability, or transportation support, depending on the intervention).
What does "integrating social care into routine medical care" mean in this FOA?
In this context, it means building social risk screening into clinical encounters and creating workable pathways that connect patients to community or social service supports that can influence diabetes management and health outcomes.
What kinds of social needs or supports are within scope?
The FOA mentions connections to supports such as transportation assistance, housing resources, food programs, and other social services that may affect diabetes management and related outcomes.
What makes an intervention "pragmatic" or "real-world" for this program?
The FOA prioritizes interventions that can be carried out within healthcare settings and that fit routine clinical operations, rather than approaches that require highly specialized conditions that are hard to sustain outside a research environment.
How important are partnerships and collaboration?
Collaboration is a major theme. NIDDK is explicitly trying to stimulate partnerships between healthcare systems and community-based organizations or social service entities, with clear and practical mechanisms for referral or service linkage.
What types of healthcare settings are relevant?
The FOA references healthcare systems such as endocrinology clinics, diabetes centers, hospitals, and primary care settings as examples of potential clinical environments where these interventions could be implemented.
What types of community partners are relevant?
Community-based organizations and social service entities that can receive referrals and provide concrete supports related to social needs (such as food, housing, and transportation) align with the intent described in the FOA.
What is the funding mechanism?
The funding mechanism is an NIH R01 grant.
What is the maximum award amount (award ceiling)?
The award ceiling listed for this opportunity is $350,000.
How is this opportunity categorized (CFDA/assistance listing)?
The funding activity category is listed under food and nutrition and health, with CFDA 93.847.
When was the opportunity created and when did it close?
The opportunity was created on January 5, 2023. The original closing date for applications was February 29, 2024.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic organizations and government entities, including state/county/city governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (other than federally recognized tribal governments); public housing authorities and Indian housing authorities; nonprofits (with or without 501(c)(3) status, other than institutions of higher education); for-profit organizations other than small businesses; and small businesses.
Are U.S. territories or possessions eligible?
Yes. The FOA explicitly includes U.S. territories or possessions among the additional eligible applicant categories.
Are specific institution types (like HBCUs or HSIs) eligible?
Yes. The FOA highlights additional eligible categories including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), among others.
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly highlights faith-based or community-based organizations as eligible applicant categories.
Are non-U.S. (foreign) organizations eligible to apply directly?
No. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply to this opportunity.
Can a U.S.-based applicant include a non-domestic (foreign) component?
Non-domestic components of U.S. organizations are not eligible. However, the FOA states that foreign components are allowed as defined in the NIH Grants Policy Statement, meaning certain foreign activities or collaborations may be included as a component of the overall project if justified and compliant with NIH policy.
What is the broader public health purpose behind this FOA?
The broader goal is to advance workable models for integrated social and medical care that can reduce inequities and improve diabetes outcomes for people whose health is shaped by unmet social needs.
Why is the FOA focused on disparities and inequities in T1D?
The FOA frames the need for coordinated systems that bridge medical treatment with social supports as a pathway to reducing disparities in T1D, particularly where unmet social needs affect access to care, adherence to treatment plans, and the daily burden of diabetes management.
What would a strong application look like based on the FOA's stated intent?
Based on the information provided, strong alignment would include: pragmatic implementation in healthcare settings, systematic screening for social risks during clinical encounters, clear referral/service linkage mechanisms, and strong operational partnerships between clinical sites and community/social service partners capable of acting on referrals.
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