Opportunity Information: Apply for W81XWH 22 LCRP IITRA
The DoD Lung Cancer Research Program (LCRP) Investigator-Initiated Translational Research Award (IITRA) is a FY22 funding opportunity from the Department of Defense, administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA), designed to push promising lung cancer research concepts toward real-world clinical use. It focuses specifically on translational research, meaning work that deliberately connects basic science and clinical observations so that discoveries made in the lab or patterns noticed in patients and populations can be shaped into tools, strategies, or interventions that matter in clinical care. A central point in this announcement is that translation is not treated as a simple one-way pipeline from bench to bedside; instead, the program expects a two-way exchange where clinical realities inform laboratory work and laboratory findings refine clinical questions, endpoints, and next steps.
The program is open to investigator-initiated ideas, which means applicants propose their own lung cancer questions and approaches rather than responding to a narrowly predefined research topic. The intent is to support projects that are advanced enough to have a clear line of sight to clinical application. The announcement highlights several examples of what fits this goal: projects that take in vitro or animal model findings and move them into validation or development using human samples or patient cohorts; late-stage preclinical studies that set up the practical foundation for a clinical trial, including activities that could support an Investigational New Drug (IND) submission; and correlative or endpoint-development studies tied to an open, ongoing, or completed clinical trial, especially when the work strengthens how trials measure response, progression, risk, or biological activity. Across these project types, the expectation is that the work is positioned to reduce the gap between discovery and patient impact, not simply generate additional early mechanistic knowledge.
A key eligibility and quality threshold is the requirement for preliminary data that are clearly relevant to lung cancer and strong enough to support feasibility of both the hypothesis and the planned approach. In other words, applicants need to show that the core idea has already been tested in a credible way and that the proposed next steps are realistic. At the same time, the program draws a firm boundary around disease scope: applications that focus only on mesothelioma are not accepted under this mechanism, even though mesothelioma can involve thoracic malignancies. The award is meant to advance lung cancer translation specifically, and proposals must be aligned accordingly.
Military health relevance is a defining feature of the LCRP and is explicitly factored into programmatic review. Applicants are expected to explain how their work connects to the healthcare needs of Service Members, Veterans, and their families, and how it supports the broader mission of the Defense Health Program (DHP). The announcement provides concrete ways to demonstrate this relevance, such as using military or Veteran populations, biospecimens, or data resources; partnering with Department of Defense or Department of Veterans Affairs investigators; or addressing military-relevant aspects of lung cancer risk, detection, or outcomes. Notably, it calls out environmental exposures other than tobacco as an example of military-relevant factors, reflecting the reality that certain occupational or deployment-related exposures may shape lung cancer risk and disease course in these communities.
From an administrative standpoint, this opportunity (Funding Opportunity Number W81XWH 22 LCRP IITRA) is listed as a discretionary program under CFDA 12.420 and uses cooperative agreements and grants as funding instruments. Eligibility is described as unrestricted (open to any type of entity), subject to any additional clarifications in the full announcement text. The funding notice was created March 16, 2022, with an original closing date of July 27, 2022, and it anticipated making about four awards. The posted award ceiling is listed as 0, which typically signals that applicants need to rely on the detailed announcement for actual budget limits or that ceilings may be handled through other sections or attachments rather than the summary field.
Overall, the IITRA mechanism is geared toward lung cancer projects that are ready to be pushed forward into clinically actionable territory, backed by convincing preliminary data, structured around a genuine bench-to-bedside-and-back feedback loop, and clearly connected to the needs and realities of military and Veteran health.Apply for W81XWH 22 LCRP IITRA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Lung Cancer, Investigator-Initiated Translational Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Mar 16, 2022.
- Applicants must submit their applications by Jul 27, 2022. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: DoD Lung Cancer Research Program (LCRP) Investigator-Initiated Translational Research Award (IITRA), FY22
What is the IITRA funding opportunity?
The Lung Cancer Research Program (LCRP) Investigator-Initiated Translational Research Award (IITRA) is a FY22 Department of Defense funding opportunity administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA). It is designed to move promising lung cancer research concepts closer to real-world clinical use.
What is the main purpose of this award?
The purpose is to support translational lung cancer research that has a clear line of sight to clinical application. The program emphasizes work that reduces the gap between discovery and patient impact, rather than projects focused only on generating additional early mechanistic knowledge.
What does the program mean by "translational research"?
Translational research here refers to work that deliberately connects basic science and clinical observations so that laboratory discoveries and patterns observed in patients or populations can be shaped into clinically meaningful tools, strategies, or interventions.
Is translation treated as a one-way "bench to bedside" pipeline?
No. A central expectation in this announcement is a two-way exchange: clinical realities should inform laboratory work, and laboratory findings should refine clinical questions, endpoints, and next steps.
Are applicants required to propose specific topics chosen by the program?
No. This mechanism is investigator-initiated, meaning applicants propose their own lung cancer questions and approaches rather than responding to a narrowly predefined research topic.
What kinds of projects are specifically highlighted as good fits?
The announcement provides examples of projects aligned with the translational goal, including:
- Moving findings from in vitro studies or animal models into validation or development using human samples or patient cohorts.
- Late-stage preclinical studies that establish the practical foundation for a clinical trial, including activities that could support an Investigational New Drug (IND) submission.
- Correlative or endpoint-development studies tied to an open, ongoing, or completed clinical trial, particularly when the work strengthens how trials measure response, progression, risk, or biological activity.
Does the program support early-stage discovery or purely mechanistic research?
The focus is on projects that are advanced enough to have a clear path toward clinical application. The expectation is to close the discovery-to-impact gap, not simply to generate additional early mechanistic knowledge.
Is preliminary data required?
Yes. A key threshold is the requirement for preliminary data that are clearly relevant to lung cancer and strong enough to support feasibility of both the hypothesis and the planned approach.
What does "strong preliminary data" mean in this context?
Based on the description, it means the core idea has already been tested in a credible way and the proposed next steps are realistic, with evidence directly relevant to lung cancer.
Are projects focused only on mesothelioma eligible?
No. Applications that focus only on mesothelioma are not accepted under this mechanism. The award is intended to advance lung cancer translation specifically.
How important is military health relevance?
Military health relevance is a defining feature of the LCRP and is explicitly factored into programmatic review. Applicants are expected to explain how the work connects to the healthcare needs of Service Members, Veterans, and their families and how it supports the mission of the Defense Health Program (DHP).
What are examples of ways to show military health relevance?
The announcement notes several concrete approaches, such as:
- Using military or Veteran populations, biospecimens, or data resources.
- Partnering with Department of Defense or Department of Veterans Affairs investigators.
- Addressing military-relevant aspects of lung cancer risk, detection, or outcomes.
- Considering environmental exposures other than tobacco as military-relevant factors (for example, occupational or deployment-related exposures).
Who administers this opportunity?
It is administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA) for the Department of Defense.
What is the Funding Opportunity Number for this announcement?
The Funding Opportunity Number listed is W81XWH 22 LCRP IITRA.
What CFDA number is associated with this opportunity?
The opportunity is listed under CFDA 12.420.
What type of funding instruments are used?
The announcement states the program uses cooperative agreements and grants as funding instruments.
Who is eligible to apply?
Eligibility is described as unrestricted (open to any type of entity), subject to any additional clarifications in the full announcement text.
When was the funding notice created and what were the key dates listed?
The notice was created on March 16, 2022. The original closing date listed is July 27, 2022.
How many awards were anticipated?
The announcement anticipated making about four awards.
What is the award ceiling for this opportunity?
The posted award ceiling is listed as 0 in the summary. This commonly indicates that applicants need to consult the detailed announcement for the actual budget limits or that ceilings are handled in other sections or attachments rather than the summary field.
What is the overall "best fit" profile for a competitive IITRA application based on this summary?
Based on the description provided, a strong fit is a lung cancer translational project that is ready to be pushed into clinically actionable territory, is backed by convincing lung cancer-relevant preliminary data, is structured around a genuine bench-to-bedside-and-back feedback loop, and clearly connects to military and Veteran health needs and realities.
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| DoD Lung Cancer, Clinical Translational Research Partnership Award Apply for W81XWH 22 LCRP CTRPA Funding Number: W81XWH 22 LCRP CTRPA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD PRMRP Discovery Award Apply for W81XWH 22 PRMRP DA Funding Number: W81XWH 22 PRMRP DA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Lung Cancer, Concept Award Apply for W81XWH 22 LCRP CA Funding Number: W81XWH 22 LCRP CA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Lung Cancer, Career Development Award Apply for W81XWH 22 LCRP CDA Funding Number: W81XWH 22 LCRP CDA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Lung Cancer, Idea Development Award Apply for W81XWH 22 LCRP IDA Funding Number: W81XWH 22 LCRP IDA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD PRMRP Investigator-Initiated Research Award Apply for W81XWH 22 PRMRP IIRA Funding Number: W81XWH 22 PRMRP IIRA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD PRMRP Clinical Trial Award Apply for W81XWH 22 PRMRP CTA Funding Number: W81XWH 22 PRMRP CTA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD PRMRP Technology/Therapeutic Development Award Apply for W81XWH 22 PRMRP TTDA Funding Number: W81XWH 22 PRMRP TTDA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
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| Ovarian Cancer Academy – Early-Career Investigator Award Apply for W81XWH 22 OCRP OCA Funding Number: W81XWH 22 OCRP OCA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Elevating Women Science and Technology Entrepreneurs and Women-Focused Startups in Asia-Pacific Economic Cooperation (APEC) Member Economies Apply for SFOP0008734 Funding Number: SFOP0008734 Agency: Department of State, Office of Acquisitions Management Category: Science and Technology and other Research and Development Funding Amount: $345,625 |
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